NORMALIZATION OF THE TUMOR MICROENVIRONMENT BY HARNESSING VASCULAR AND IMMUNE MODULATION TO ACHIEVE ENHANCED CANCER THERAPY

Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

Abstract Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth.Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment.Despite attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pruning has shown li

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Phylogeographic Structure in Penguin Ticks across an Ocean Basin Indicates Allopatric Divergence and Rare Trans-Oceanic Dispersal.

The association of ticks (Acarina) and seabirds provides an intriguing system for assessing the influence of long-distance dispersal on the evolution of parasitic species.Recent research has focused on host-parasite evolutionary relationships and dispersal capacity of ticks parasitising flighted seabirds.Evolutionary research on the ticks of non-fl

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Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1: A Systematic Review

Aim.To systematically review the role of positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG) in patients with neurofibromatosis type 1 (NF1).Methods.A comprehensive literature search of Console Interface published studies regarding FDG-PET and PET/CT in patients with NF1 was performed.No beginning date limit and language re

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Lamotrigine hypersensitivity syndrome and spiking fever

We report a case of a 26 year old woman with rash, lymphadenopathy, liver enzyme abnormalities and spiking fever.She was diagnosed with drug-induced hypersensitivity syndrome (DHS) to lamotrigine.Spiking fever in relation to drug-induced hypersensitivity syndrome has not earlier Honeysuckle been described in adults.Spiking fever is an important sym

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